{"id":25932,"date":"2025-11-16T19:31:33","date_gmt":"2025-11-16T11:31:33","guid":{"rendered":"https:\/\/pi-union.com\/?p=25932"},"modified":"2026-02-04T11:26:27","modified_gmt":"2026-02-04T03:26:27","slug":"%e7%82%ba%e4%bb%80%e9%ba%bc%e9%af%a8%e9%ad%9a%e4%b8%8d%e6%9c%83%e5%be%97%e7%99%8c%e7%97%87","status":"publish","type":"post","link":"https:\/\/pi-union.com\/en\/2025\/11\/16\/%e7%82%ba%e4%bb%80%e9%ba%bc%e9%af%a8%e9%ad%9a%e4%b8%8d%e6%9c%83%e5%be%97%e7%99%8c%e7%97%87\/","title":{"rendered":"\u70ba\u4ec0\u9ebc\u9be8\u9b5a\u4e0d\u6703\u5f97\u764c\u75c7?"},"content":{"rendered":"<h3 class=\"wp-block-heading\"><strong>\u9577\u58fd\u7684\u5f13\u982d\u9be8\u5177\u6709\u66f4\u4f73<\/strong><strong> DNA <\/strong><strong>\u4fee\u5fa9\u80fd\u529b\u7684\u8b49\u64da<\/strong><strong><\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Denis Firsanov et al.<\/li>\n\n\n\n<li><strong><em>Nature<\/em><\/strong><\/li>\n\n\n\n<li>29 October 2025.<\/li>\n<\/ul>\n\n\n\n<p><strong>\u8d85\u904e 200 <\/strong><strong>\u5e74\u7684\u6700\u5927\u58fd\u547d\uff0c\u4f7f\u5f13\u982d\u9be8\u6210\u70ba\u58fd\u547d\u6700\u9577\u7684\u54fa\u4e73\u52d5\u7269\u3002\u5f13\u982d\u9be8\u4e5f\u662f\u5730\u7403\u4e0a\u7b2c\u4e8c\u5927\u7684\u52d5\u7269\uff0c\u9ad4\u91cd\u53ef\u8d85\u904e 80,000 <\/strong><strong>\u516c\u65a4\u3002\u5118\u7ba1\u5b83\u64c1\u6709\u6975\u5927\u91cf\u7684\u7d30\u80de\u8207\u6975\u9577\u7684\u58fd\u547d\uff0c\u5f13\u982d\u9be8\u537b\u4e26\u4e0d\u5bb9\u6613\u7f79\u764c\uff0c\u800c\u9019\u7a2e\u4e0d\u4e00\u81f4\u7684\u73fe\u8c61\u88ab\u7a31\u70ba\u76ae\u6258\u6096\u8ad6\uff08Peto\u2019s paradox<\/strong><strong>\uff09\u3002<\/strong><\/p>\n\n\n\n<p>\u70ba\u4e86\u7406\u89e3\u5f13\u982d\u9be8\u6297\u764c\u6a5f\u5236\u7684\u539f\u7406\uff0c\u6211\u5011\u5206\u6790\u4e86\u5f13\u982d\u9be8\u539f\u4ee3\u7e96\u7dad\u6bcd\u7d30\u80de\u767c\u751f\u60e1\u6027\u8f49\u5316\u6240\u9700\u7684\u81f4\u764c\u6253\u64ca\uff08oncogenic hits\uff09\u6578\u91cf\u3002\u51fa\u4e4e\u610f\u6599\u7684\u662f\uff0c\u5f13\u982d\u9be8\u7e96\u7dad\u6bcd\u7d30\u80de\u9032\u884c\u60e1\u6027\u8f49\u5316\u6240\u9700\u7684\u81f4\u764c\u6253\u64ca\u6b21\u6578\uff0c\u7adf\u7136\u6bd4\u4eba\u985e\u7e96\u7dad\u6bcd\u7d30\u80de\u9084\u5c11\u3002\u7136\u800c\uff0c\u5f13\u982d\u9be8\u7d30\u80de\u5c55\u73fe\u51fa\u589e\u5f37\u7684 DNA \u96d9\u80a1\u65b7\u88c2\u4fee\u5fa9\u80fd\u529b\u8207\u9ad8\u4fdd\u771f\u6027\uff0c\u4e26\u4e14\u5176\u7a81\u8b8a\u7387\u4f4e\u65bc\u5176\u4ed6\u54fa\u4e73\u52d5\u7269\u7684\u7d30\u80de\u3002<\/p>\n\n\n\n<p>\u6211\u5011\u767c\u73fe\u51b7\u8a98\u5c0e RNA \u7d50\u5408\u86cb\u767d CIRBP \u5728\u5f13\u982d\u9be8\u7684\u7e96\u7dad\u6bcd\u7d30\u80de\u548c\u7d44\u7e54\u4e2d\u9ad8\u5ea6\u8868\u9054\u3002\u5f13\u982d\u9be8\u7684 CIRBP \u80fd\u589e\u5f37\u4eba\u985e\u7d30\u80de\u4e2d\u7684\u975e\u540c\u6e90\u7aef\u63a5\uff08NHEJ\uff09\u8207\u540c\u6e90\u91cd\u7d44\uff08HR\uff09\u4fee\u5fa9\uff0c\u964d\u4f4e\u5fae\u6838\u5f62\u6210\u3001\u4fc3\u9032 DNA \u672b\u7aef\u4fdd\u8b77\uff0c\u4e26\u5728\u9ad4\u5916\u523a\u6fc0\u7aef\u63a5\u53cd\u61c9\u3002\u5728\u679c\u8805\u4e2d\uff0c\u904e\u5ea6\u8868\u9054 CIRBP \u80fd\u5ef6\u9577\u58fd\u547d\u4e26\u63d0\u9ad8\u6297\u8f3b\u5c04\u80fd\u529b\u3002<\/p>\n\n\n\n<p>\u9019\u4e9b\u767c\u73fe\u652f\u6301\u4e00\u9805\u5047\u8aaa\uff1a\u5f13\u982d\u9be8\u4e26\u975e\u4f9d\u8cf4\u984d\u5916\u7684\u816b\u7624\u6291\u5236\u57fa\u56e0\u4f86\u907f\u514d\u81f4\u764c\uff0c\u800c\u662f\u900f\u904e\u5f37\u5316\u7684 DNA \u4fee\u5fa9\u80fd\u529b\u4f86\u7dad\u6301\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\u3002\u9019\u7a2e\u7b56\u7565\u4e0d\u662f\u6e05\u9664\u53d7\u640d\u7d30\u80de\uff0c\u800c\u662f\u7cbe\u78ba\u5730\u4fee\u5fa9\u5b83\u5011\uff0c\u53ef\u80fd\u6b63\u662f\u5f13\u982d\u9be8\u64c1\u6709\u9a5a\u4eba\u9577\u58fd\u8207\u4f4e\u764c\u75c7\u767c\u751f\u7387\u7684\u539f\u56e0\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u54fa\u4e73\u52d5\u7269\u5408\u4f5c\u751f\u6d3b\u65b9\u5f0f\u8207\u764c\u75c7\u76db\u884c\u7387\u4e0b\u964d\u7684\u5171\u540c\u6f14\u5316<\/strong><\/h3>\n\n\n\n<p>Catalina Sierra et al.<\/p>\n\n\n\n<p><strong><em>Science Advances<\/em><\/strong><\/p>\n\n\n\n<p>12 Nov 2025. Vol 11, Issue 46.<\/p>\n\n\n\n<p>\u70ba\u4ec0\u9ebc\u5728\u4e00\u4e9b\u7269\u7a2e\u5df2\u7d93\u6f14\u5316\u51fa\u6297\u764c\u6a5f\u5236\u7684\u60c5\u6cc1\u4e0b\uff0c\u764c\u75c7\u5728\u54fa\u4e73\u52d5\u7269\u4e2d\u4ecd\u7136\u5982\u6b64\u666e\u904d\uff0c\u81f3\u4eca\u4ecd\u662f\u672a\u89e3\u4e4b\u8b0e\u3002\u6211\u5011\u5047\u8a2d\uff0c\u764c\u75c7\u7684\u76db\u884c\u7387\u8207\u6b7b\u4ea1\u98a8\u96aa\u53ef\u80fd\u5df2\u7d93\u88ab\u6f14\u5316\u7cbe\u7d30\u8abf\u7bc0\u3002\u6211\u5011\u5229\u7528\u516c\u958b\u8cc7\u6599\u5eab\u986f\u793a\uff1a<strong>\u5177\u6709\u5408\u4f5c\u884c\u70ba\u7684\u7269\u7a2e\uff0c\u5176\u764c\u75c7\u76db\u884c\u7387\u8207\u6b7b\u4ea1\u98a8\u96aa\u8f03\u4f4e\u3002<\/strong><\/p>\n\n\n\n<p>\u900f\u904e\u5efa\u7acb\u6578\u5b78\u6a21\u578b\uff0c\u6211\u5011\u63d0\u51fa\u4e00\u500b\u6a5f\u5236\u6027\u7684\u89e3\u91cb\uff1a\u4e00\u7a2e\u81f4\u764c\u8b8a\u7570\u5982\u679c\u4f7f\u5e74\u9577\u4e14\u751f\u6b96\u80fd\u529b\u8f03\u4f4e\u7684\u500b\u9ad4\u627f\u53d7\u8f03\u9ad8\u7684\u764c\u75c7\u6b7b\u4ea1\u7387\uff0c\u5c0d\u5408\u4f5c\u578b\u54fa\u4e73\u52d5\u7269\u793e\u6703\u662f\u4e0d\u5229\u7684\uff1b\u4f46\u5728\u7af6\u722d\u578b\u7684\u751f\u614b\u74b0\u5883\u4e2d\uff0c\u8a72\u8b8a\u7570\u537b\u53ef\u80fd\u5c0e\u81f4\u7a2e\u7fa4\u898f\u6a21\u8207\u9069\u5408\u5ea6\u51fa\u73fe\u300c\u53cd\u76f4\u89ba\u6027\u7684\u904e\u5ea6\u88dc\u511f\u300d\u6548\u61c9\u3002<\/p>\n\n\n\n<p>\u9019\u7a2e\u300c\u7576\u500b\u9ad4\u5b58\u6d3b\u7387\u4e0b\u964d\uff0c\u537b\u4f7f\u65cf\u7fa4\u6578\u91cf\u53cd\u800c\u4e0a\u5347\u300d\u7684\u73fe\u8c61\uff0c\u88ab\u7a31\u70ba<strong>\u4e5d\u982d\u86c7\u6548\u61c9\uff08hydra effect\uff09<\/strong>\uff0c\u800c\u6b64\u6548\u61c9\u5728\u764c\u75c7\u9818\u57df\u4e2d\u904e\u53bb\u5f9e\u672a\u88ab\u63a2\u8a0e\u3002\u56e0\u6b64\uff0c\u764c\u75c7\u53ef\u4ee5\u88ab\u8996\u70ba\u7af6\u722d\u6027\u7269\u7a2e\u4e2d\uff0c\u7d93\u904e\u9078\u64c7\u6240\u5f62\u5851\u7684\u4e00\u7a2e\u300c\u751f\u7269\u6027\u6c70\u820a\u6a5f\u5236\u300d\uff08biological obsolescence\uff09\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Source 1: <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09694-5\">https:\/\/www.nature.com\/articles\/s41586-025-09694-5<\/a><\/p>\n\n\n\n<p>Source 2: <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adw0685\">https:\/\/www.science.org\/doi\/10.1126\/sciadv.adw0685<\/a> <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>Translator:\u00a0<a href=\"https:\/\/course.pi-union.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">PI-Union Medical Science Ltd.<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>E-mail:\u00a0<a href=\"mailto:piunion@pi-union.com\">piunion@pi-union.com<\/a><\/li>\n\n\n\n<li>Official Website:\u00a0<a href=\"https:\/\/pi-union.com\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pi-union.com\/<\/a><\/li>\n\n\n\n<li>Facebook:\u00a0<a href=\"https:\/\/www.facebook.com\/piunion2020\/\" target=\"_blank\" rel=\"noreferrer noopener\">www.facebook.com\/piunion2020<\/a><\/li>\n\n\n\n<li>Youtube:\u00a0<a href=\"https:\/\/www.youtube.com\/@pi-union\">www.youtube.com\/@pi-union<\/a><\/li>\n\n\n\n<li>Instagram:\u00a0<a href=\"https:\/\/www.instagram.com\/piunion2020\/\">www.instagram.com\/piunion2020<\/a><\/li>\n\n\n\n<li>LINE: @654eukag<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u9577\u58fd\u7684\u5f13\u982d\u9be8\u5177\u6709\u66f4\u4f73 DNA \u4fee\u5fa9\u80fd\u529b\u7684\u8b49\u64da \u8d85\u904e 200 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":25933,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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