Body – PI-Union Medical Science Ltd. https://pi-union.com PI-Union Medical Science Ltd. Wed, 04 Feb 2026 03:49:27 +0000 zh-TW hourly 1 https://wordpress.org/?v=7.0 https://pi-union.com/wp-content/uploads/2022/12/cropped-favicon-32x32.png Body – PI-Union Medical Science Ltd. https://pi-union.com 32 32 Three Poisons as the Root Causes of Illness https://pi-union.com/2026/01/04/purifying-the-three-karmas-the-path-toward-liberation/ https://pi-union.com/2026/01/04/purifying-the-three-karmas-the-path-toward-liberation/#respond Sun, 04 Jan 2026 11:47:52 +0000 https://pi-union.com/?p=25969 Purifying the Three Karmas: The Path Toward Liberation

By Chuan-Sung
Puzhen Monastery, Taichung, Taiwan.

Having worked in the medical field for many years, I have observed that the causes of many illnesses often remain elusive. Patients with the same diagnosis, treated by the same physician and prescribed the same medications, may nonetheless experience vastly different outcomes. Some individuals visit hospital after hospital, yet their long-standing symptoms remain unresolved. It was only after encountering the Buddha’s teachings and gaining an understanding of the three karmas—body, speech, and mind—rooted in the Three Poisons of greed, anger, and ignorance, that I gradually came to realize that human illness arises not only from physiological pathology, but also from these deeply embedded mental afflictions.

The Three Poisons resemble chronic toxins hidden within the depths of consciousness, silently eroding physical health, emotional stability, and interpersonal relationships over time.

The Fires of the Three Poisons Arise from the Mind

The Three Poisons constitute the fundamental roots of both physical and mental illness. Greed is like persistently elevated blood glucose stimulating the brain’s reward system, repeatedly triggering dopamine release and producing fleeting satisfaction. Over time, tolerance develops, leading to addictive behaviors, material craving, dietary imbalance, and eventually chronic disease. Anger, on the other hand, keeps individuals in a prolonged state of resentment and rage, disrupting autonomic nervous system regulation and contributing to hypertension, palpitations, depression, and irritability. Ignorance manifests as distorted understanding—misconceptions about illness that lead to maladaptive behaviors and views, such as denial of one’s condition, refusal to follow medical advice, blaming others, or trusting unverified folk remedies. These often result in unnecessary financial loss, adverse side effects, and ultimately entrapment in the vicious cycle of delusion, karma, and suffering.

As the Buddhist saying goes, “The blazing fires of the Three Poisons constantly burn all sentient beings.” Without fundamentally addressing these internal sources of illness, even the most advanced medications or treatments can offer only symptomatic relief rather than true healing.

Precepts, Concentration, and Wisdom: Purifying the Three Karmas

How, then, can we address illness at its root? Conventional medical systems primarily focus on acute intervention or symptomatic treatment. The Buddha’s teachings, however, offer not only preventive medicine but a truly radical therapy.

To counter greed, one cultivates precepts. Moral discipline functions much like lifestyle management, preventing harmful behaviors such as uncontrolled eating, substance addiction, excessive consumption, gambling, and obsessive pursuit of wealth.

To counter anger, one cultivates concentration. Meditation practices—including seated meditation and the practice of śamatha (calm-abiding) and vipaśyanā (insight meditation)—serve as powerful tools for emotional regulation and stress management. Repentance and cognitive reframing parallel psychotherapeutic processes, helping individuals transform anger, jealousy, resentment, and hatred into calmness and renewal.

At the core lies wisdom, the antidote to ignorance. Through a wisdom-based understanding of causality and the contemplative view of dependent origination and emptiness (pratītyasamutpāda–śūnyatā), one can reinterpret the formation of illness, life’s suffering, and interpersonal conflict. Wisdom dissolves delusion and guides one toward genuine liberation and holistic well-being.

Integrating Medicine and Dharma

A common proverb states, “Illness enters through the mouth; misfortune leaves through the mouth.” Many chronic diseases arise from indulgence in sensory pleasures, particularly dietary excess. In such cases, biomedical treatment must be complemented by wisdom-based guidance grounded in karmic causality, as well as moral discipline to correct harmful habits.

Similarly, modern psychosomatic conditions—such as insomnia, headaches, chest tightness, palpitations, depression, and social anxiety—often stem from an inability to process external stressors. Alongside medical evaluation and diagnostic testing, practices such as breath-counting meditation, contemplative reflection, and altruistic service can significantly improve these conditions.

For me, a life of wisdom represents integrated health of body, mind, and spirit. Wisdom does not mean worldly success or exceptional technical skill, but the ability to restrain desire without being enslaved by greed; to transform emotions without being wounded by anger; and to recognize truth without being misled by ignorance.

As a healthcare professional, I aspire to practice medicine with the heart of a healer while walking the path of the Bodhisattva—applying the Buddha’s teachings both in clinical practice and personal cultivation. This approach benefits not only patients, but also safeguards one’s own physical and mental well-being.

The Buddha as the Great Physician

The Buddha is revered as the Great Physician—one who understands the root causes of sentient beings’ suffering. The prescriptions He offers are wisdom, the therapeutic process is compassion, and the ultimate vision is liberation. I aspire to learn and embody this healing path, beginning with the purification of the Three Karmas and the eradication of the Three Poisons—healing not only the body, but also the mind, and walking together with all beings toward the path of wisdom and liberation.

Source: https://www.ctworld.org.tw/monthly/311/a03-05.htm

Translator: PI-Union Medical Science Ltd.

]]> https://pi-union.com/2026/01/04/purifying-the-three-karmas-the-path-toward-liberation/feed/ 0 機體自主細胞改造：以mRNA技術驅動CAR-T細胞生成之癌症與自體免疫疾病新興治療策略 https://pi-union.com/2025/07/21/%e6%a9%9f%e9%ab%94%e8%87%aa%e4%b8%bb%e7%b4%b0%e8%83%9e%e6%94%b9%e9%80%a0%ef%bc%9a%e4%bb%a5mrna%e6%8a%80%e8%a1%93%e9%a9%85%e5%8b%95car-t%e7%b4%b0%e8%83%9e%e7%94%9f%e6%88%90%e4%b9%8b%e7%99%8c%e7%97%87/ https://pi-union.com/2025/07/21/%e6%a9%9f%e9%ab%94%e8%87%aa%e4%b8%bb%e7%b4%b0%e8%83%9e%e6%94%b9%e9%80%a0%ef%bc%9a%e4%bb%a5mrna%e6%8a%80%e8%a1%93%e9%a9%85%e5%8b%95car-t%e7%b4%b0%e8%83%9e%e7%94%9f%e6%88%90%e4%b9%8b%e7%99%8c%e7%97%87/#respond Mon, 21 Jul 2025 12:56:35 +0000 https://pi-union.com/?p=25859 《Science》期刊於2025年6月19日由Mitch Leslie報導一篇創新研究：該研究提出一種新穎策略，利用mRNA注射技術在體內直接誘導產生CAR-T細胞，有望用於治療癌症及自體免疫疾病，並大幅簡化製程、降低成本。

🔍 背景

  • CAR-T 細胞是經基因改造的 T 細胞，可精準攻擊癌細胞，已獲美國 FDA 核准用於某些血癌。
  • 製造傳統 CAR-T 細胞須從患者體內採集 T 細胞 → 純化 → 基因改造 → 輸回體內，過程耗時且昂貴（最高達百萬美元），部分病患無法等候完成治療。

🧪 創新研究

  • Capstan Therapeutics 開發一種新方法，利用 mRNA 脂質奈米微粒（Lipid nanoparticle, LNP） 直接注射進入體內誘導 T 細胞自行轉化為 CAR-T 細胞。
  • 這項方法靈感來自於 mRNA COVID-19 疫苗技術，且不需更改基因組，較具安全性。

🐁 實驗成果

  • 在小鼠中注射mRNA奈米微粒後，體內快速產生大量CAR-T細胞（3小時內即出現於血液、脾臟、淋巴）。
  • 高劑量治療組中，腫瘤在3天內幾乎消失。
  • 在猴子實驗中，mRNA誘導的CAR-T細胞成功清除B細胞並於7週內自然恢復，有望「重設」免疫系統，應用於自體免疫疾病。

✅ 優點

  • 速度快：無需體外改造與輸回體內，治療時間大幅縮短。
  • 成本低：製造成本可能遠低於目前的細胞工廠流程。
  • 更安全：mRNA不整合進DNA，可自然分解，具「自動關閉」機制，減少長期副作用。

⚠ 潛在風險與挑戰

  • 一隻猴子出現類似實驗室CAR-T治療常見的重度免疫副作用。
  • 安全性仍需進一步臨床試驗驗證（Capstan已啟動Phase 1試驗）。

🧩 未來展望

  • 此技術若證實安全有效，可望普及CAR-T細胞療法至更多癌症與自體免疫疾病。
  • 有望成為即時可用的標準化治療選項，取代繁複且昂貴的細胞製備流程。

評論:

🧪 科學貢獻與創新性

這項研究突破了傳統CAR-T細胞需經體外操作的限制，首次展示可透過mRNA奈米微粒直接在體內誘導CAR-T細胞生成，大幅簡化技術流程，並以動物實驗證實其有效性與初步安全性。

  • 借助 COVID-19 疫苗的 mRNA 傳遞平台，研究團隊成功將此機制應用於複雜的細胞治療領域。
  • 在短短數小時內於小鼠與猴子體內產生功能性CAR-T細胞，展現即時且可控的治療反應。

此方法若進一步證實安全有效，將徹底改變CAR-T療法的製造與給藥方式，使其從「個人化、客製化」走向「即時可用、模組化」，具有高度臨床轉譯潛力。

💡 臨床應用潛力

  • 癌症治療： 高劑量治療下腫瘤迅速縮小，展現CAR-T功能性；若能安全應用於人體，將有助提升對實體瘤的反應效率。
  • 自體免疫疾病： 在猴子中清除B細胞並自然恢復，暗示可透過「免疫重置」治療如紅斑性狼瘡、多發性硬化症等疾病。
  • 經濟與可近性： 有望大幅降低目前高達百萬美元的療程費用，提高全球可及性。

⚠ 侷限與挑戰

  1. 安全性問題尚未解決：
    一隻猴子出現嚴重發炎反應，與現有CAR-T細胞副作用相似，突顯此技術雖無基因整合風險，但仍可能引發毒性反應。
  2. mRNA轉染效率與時效性控制：
    雖具「自動關閉」優勢，但如何精準控制CAR表現量與時間仍有待優化，避免過度免疫活化或治療反彈。
  3. 臨床資料仍屬前期：
    目前僅限動物模型，尚需臨床試驗驗證在人類身上的可行性與安全邊界。

🔭 總結與展望

這篇文章所報導的技術具備轉變CAR-T治療的潛力，從實驗室製造邁向體內合成，為癌症與自體免疫疾病提供全新治療可能。然而，安全性與可控性將是臨床應用的關鍵門檻。未來若能在人體試驗中克服副作用並證實療效，此策略或將成為下一代細胞療法的主流平台。

Source: New approach enables body to engineer its own cells to fight cancer or autoimmunity

Translator and Reviewer: PI-Union Medical Science Ltd.

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