{"id":25498,"date":"2025-05-11T10:45:09","date_gmt":"2025-05-11T02:45:09","guid":{"rendered":"https:\/\/pi-union.com\/?p=25498"},"modified":"2025-05-15T18:14:30","modified_gmt":"2025-05-15T10:14:30","slug":"%e5%a4%aa%e7%a9%ba%e8%bc%bb%e5%b0%84%e7%92%b0%e5%a2%83%e4%b8%ad%e7%9a%84%e7%ab%af%e7%b2%92%e8%88%87dna%e6%90%8d%e5%82%b7%e5%8f%8d%e6%87%89%e7%9a%84%e6%99%82%e9%96%93%e6%80%a7%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/pi-union.com\/zh\/2025\/05\/11\/%e5%a4%aa%e7%a9%ba%e8%bc%bb%e5%b0%84%e7%92%b0%e5%a2%83%e4%b8%ad%e7%9a%84%e7%ab%af%e7%b2%92%e8%88%87dna%e6%90%8d%e5%82%b7%e5%8f%8d%e6%87%89%e7%9a%84%e6%99%82%e9%96%93%e6%80%a7%e7%a0%94%e7%a9%b6\/","title":{"rendered":"\u592a\u7a7a\u8f90\u5c04\u73af\u5883\u4e2d\u7684\u7aef\u7c92\u4e0eDNA\u635f\u4f24\u53cd\u5e94\u7684\u65f6\u95f4\u6027\u7814\u7a76"},"content":{"rendered":"

\u592a\u7a7a\u8f3b\u5c04\u74b0\u5883\u4e2d\u7684\u7aef\u7c92\u8207<\/strong>DNA<\/strong>\u640d\u50b7\u53cd\u61c9\u7684\u6642\u9593\u6027\u7814\u7a76<\/strong><\/h3>\n\n\n\n

Jared J Luxton et al.<\/p>\n\n\n\n

Cell Rep.<\/em> 2020 Dec 8;33(10):108435.<\/p>\n\n\n\n

\u6458\u8981<\/strong>
\u7aef\u7c92(Telomeres)\u662f\u67d3\u8272\u9ad4\u672b\u7aef\u7684\u91cd\u8907\u7279\u5fb5\uff0c\u5c0d\u7dad\u6301\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\u81f3\u95dc\u91cd\u8981\uff0c\u96a8\u8457\u7d30\u80de\u5206\u88c2\u3001\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u3001\u58d3\u529b\u548c\u74b0\u5883\u66b4\u9732\u800c\u7e2e\u77ed\uff0c\u56e0\u6b64\u5b83\u5011\u63d0\u4f9b\u4e86\u4e00\u500b\u5f37\u5065\u7684\u5065\u5eb7\u3001\u8001\u5316\u548c\u8207\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7684\u751f\u7269\u6a19\u8a18\u3002<\/p>\n\n\n\n

\u6211\u5011\u8a55\u4f30\u4e86\u4e09\u540d\u76f8\u4e92\u7121\u95dc\u4fc2\u7684\u592a\u7a7a\u4eba\u5728\u570b\u969b\u592a\u7a7a\u7ad9\uff08International Space Station, ISS\uff09\u9032\u884c1\u5e74\u62166\u500b\u6708\u4efb\u52d9\u524d\u3001\u4efb\u52d9\u4e2d\u548c\u4efb\u52d9\u5f8c\u7684\u7aef\u7c92\u9577\u5ea6\u52d5\u614b\uff08\u96a8\u6642\u9593\u8b8a\u5316\uff09\u3002<\/p>\n\n\n\n

\u8207\u6211\u5011\u5728\u7f8e\u570b\u570b\u5bb6\u822a\u7a7a\u66a8\u592a\u7a7a\u7e3d\u7f72\uff08NASA\uff09\u76841\u5e74\u4efb\u52d9\u96d9\u80de\u80ce\u592a\u7a7a\u4eba\uff08Garrett-Bakelman et al., 2019\uff09\u7684\u7814\u7a76\u7d50\u679c\u985e\u4f3c\uff0c\u5169\u540d6\u500b\u6708\u4efb\u52d9\u7684\u592a\u7a7a\u4eba\u5728\u592a\u7a7a\u98db\u884c\u671f\u9593\u89c0\u5bdf\u5230\u4e86\u986f\u8457\u8f03\u9577\u7684\u7aef\u7c92\u3002<\/strong><\/p>\n\n\n\n

\u6b64\u5916\uff0c\u4e09\u540d\u6a5f\u7d44\u6210\u54e1\u8fd4\u56de\u5730\u7403\u5f8c\u7aef\u7c92\u9577\u5ea6\u8fc5\u901f\u7e2e\u77ed\uff0c\u7e3d\u9ad4\u4f86\u770b\uff0c\u592a\u7a7a\u98db\u884c\u5f8c\u7684\u7aef\u7c92\u9577\u5ea6\u5f80\u5f80\u6bd4\u592a\u7a7a\u98db\u884c\u524d\u66f4\u77ed\u3002<\/strong>\u8207\u9577\u671f\u66b4\u9732\u65bc\u592a\u7a7a\u8f3b\u5c04\u74b0\u5883\u4e00\u81f4\uff0c\u9084\u6aa2\u6e2c\u5230\u4e86\u6301\u7e8c\u7684DNA\u640d\u50b7\u53cd\u61c9\u7684\u7279\u5fb5\uff0c\u5305\u62ec\u7c92\u7dda\u9ad4\u548c\u6c27\u5316\u58d3\u529b\u3001\u708e\u75c7\uff0c\u4ee5\u53ca\u7aef\u7c92\u548c\u67d3\u8272\u9ad4\u7578\u8b8a\uff0c\u9019\u4e9b\u7279\u5fb5\u5171\u540c\u70ba\u592a\u7a7a\u98db\u884c\u7279\u6709\u7684\u7aef\u7c92\u5ef6\u9577\u63d0\u4f9b\u4e86\u6f5b\u5728\u7684\u6a5f\u5236\u6027\u898b\u89e3\u3002<\/p>\n\n\n\n

\n\n\n\n

\u9019\u7bc7\u7531Jared J Luxton\u7b49\u4eba\u65bc2020\u5e74\u767c\u8868\u65bc\u300aCell Reports\u300b\u7684\u7814\u7a76\uff0c\u805a\u7126\u65bc\u592a\u7a7a\u8f3b\u5c04\u74b0\u5883\u4e2d\u7aef\u7c92\u9577\u5ea6\u53caDNA\u640d\u50b7\u53cd\u61c9\u7684\u6642\u9593\u6027\u8b8a\u5316\uff0c\u70ba\u7406\u89e3\u592a\u7a7a\u4efb\u52d9\u5c0d\u4eba\u9ad4\u7d30\u80de\u5065\u5eb7\u7684\u5f71\u97ff\u63d0\u4f9b\u4e86\u95dc\u9375\u7684\u52d5\u614b\u89c0\u5bdf\u8cc7\u6599\u3002<\/p>\n\n\n\n

    \n
  1. \u52d5\u614b\u76e3\u6e2c\u7aef\u7c92\u9577\u5ea6\u7684\u5275\u65b0\u8a2d\u8a08<\/strong>
    \u672c\u7814\u7a76\u8ffd\u8e64\u4e86\u4e09\u4f4d\u4e0d\u540c\u592a\u7a7a\u4eba\u5728ISS\u57f7\u884c\u9577\u77ed\u671f\uff086\u500b\u6708\u81f31\u5e74\uff09\u4efb\u52d9\u671f\u9593\u53ca\u8fd4\u56de\u5730\u7403\u524d\u5f8c\u7684\u7aef\u7c92\u9577\u5ea6\u8b8a\u5316\uff0c\u5229\u7528\u6642\u9593\u5e8f\u5217\u8cc7\u6599\u63ed\u793a\u4e86\u7aef\u7c92\u9577\u5ea6\u7684\u96d9\u5411\u6ce2\u52d5\u3002\u9019\u7a2e\u7e1d\u5bc6\u7684\u6642\u9593\u6027\u8ffd\u8e64\u76f8\u8f03\u65bc\u50b3\u7d71\u55ae\u9ede\u6bd4\u8f03\uff0c\u66f4\u80fd\u53cd\u6620\u592a\u7a7a\u74b0\u5883\u5c0d\u7d30\u80de\u8001\u5316\u6307\u6a19\u7684\u5373\u6642\u548c\u5ef6\u9072\u5f71\u97ff\uff0c\u5177\u6709\u8f03\u9ad8\u7684\u79d1\u5b78\u50f9\u503c\u3002<\/li>\n\n\n\n
  2. \u7aef\u7c92\u5ef6\u9577\u8207\u96a8\u5f8c\u7e2e\u77ed\u7684\u751f\u7269\u5b78\u610f\u7fa9<\/strong>
    \u7814\u7a76\u767c\u73fe\u592a\u7a7a\u4efb\u52d9\u4e2d\u7aef\u7c92\u51fa\u73fe\u986f\u8457\u5ef6\u9577\uff0c\u4f46\u8fd4\u56de\u5730\u7403\u5f8c\u7aef\u7c92\u8fc5\u901f\u7e2e\u77ed\uff0c\u4e14\u4efb\u52d9\u7d50\u675f\u5f8c\u7aef\u7c92\u666e\u904d\u6bd4\u4efb\u52d9\u524d\u66f4\u77ed\u3002\u9019\u7a2e\u975e\u7dda\u6027\u8b8a\u5316\u63d0\u793a\u592a\u7a7a\u74b0\u5883\uff08\u5982\u5fae\u91cd\u529b\u3001\u8f3b\u5c04\uff09\u53ef\u80fd\u8a98\u767c\u7d30\u80de\u7aef\u7c92\u8abf\u63a7\u7684\u58d3\u529b\u53cd\u61c9\uff08stress response)\uff0c\u985e\u4f3c\u7aef\u7c92\u9176\u6d3b\u6027\u77ed\u66ab\u4e0a\u8abf\uff0c\u4f46\u96a8\u5f8c\u56e0\u8f3b\u5c04\u9020\u6210\u7684DNA\u640d\u50b7\u548c\u6c27\u5316\u58d3\u529b\u800c\u52a0\u901f\u7aef\u7c92\u8017\u640d\uff0c\u63ed\u793a\u4e86\u592a\u7a7a\u751f\u7406\u5b78\u4e2d\u8907\u96dc\u7684\u7d30\u80de\u8001\u5316\u6a5f\u5236\u3002<\/li>\n\n\n\n
  3. DNA\u640d\u50b7\u53cd\u61c9\u8207\u7d30\u80de\u58d3\u529b\u6a19\u8a18\u7684\u6301\u7e8c\u5b58\u5728<\/strong>
    \u6587\u7ae0\u6307\u51fa\u6301\u7e8c\u7684DNA\u640d\u50b7\u53cd\u61c9\u5305\u62ec\u7c92\u7dda\u9ad4\u529f\u80fd\u7570\u5e38\u3001\u6c27\u5316\u58d3\u529b\u8207\u708e\u75c7\uff0c\u9019\u4e9b\u5747\u662f\u7aef\u7c92\u7e2e\u77ed\u548c\u67d3\u8272\u9ad4\u7578\u8b8a\u7684\u6f5b\u5728\u9a45\u52d5\u56e0\u5b50\uff0c\u5f37\u8abf\u592a\u7a7a\u8f3b\u5c04\u5c0d\u7d30\u80de\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\u7684\u9577\u671f\u5a01\u8105\u3002\u9019\u4e00\u767c\u73fe\u5c0d\u672a\u4f86\u592a\u7a7a\u4eba\u5065\u5eb7\u7ba1\u7406\u548c\u8f3b\u5c04\u9632\u8b77\u7b56\u7565\u63d0\u4f9b\u4e86\u751f\u7269\u6a19\u8a18\u7684\u4f9d\u64da\u3002<\/li>\n\n\n\n
  4. \u8207\u5148\u524d\u96d9\u80de\u80ce\u7814\u7a76\u7684\u547c\u61c9\u8207\u64f4\u5c55<\/strong>
    \u672c\u6587\u7d50\u679c\u8207Garrett-Bakelman\u7b49\u4eba2019\u5e74NASA\u96d9\u80de\u80ce\u7814\u7a76\u4e2d\u89c0\u5bdf\u5230\u7684\u7aef\u7c92\u8b8a\u5316\u76f8\u4f3c\uff0c\u9032\u4e00\u6b65\u9a57\u8b49\u4e86\u592a\u7a7a\u98db\u884c\u5c0d\u7aef\u7c92\u52d5\u614b\u7684\u5f71\u97ff\uff0c\u4e26\u64f4\u5927\u4e86\u6a23\u672c\u591a\u6a23\u6027\u548c\u6642\u9593\u8de8\u5ea6\uff0c\u4f7f\u7814\u7a76\u7d50\u679c\u66f4\u5177\u666e\u904d\u6027\u548c\u53ef\u9760\u6027\u3002<\/li>\n\n\n\n
  5. \u672a\u4f86\u7814\u7a76\u7684\u6311\u6230\u8207\u65b9\u5411<\/strong>
    \u672c\u7814\u7a76\u63d0\u9192\u6211\u5011\u9700\u6df1\u5165\u63a2\u8a0e\u7aef\u7c92\u52d5\u614b\u8abf\u63a7\u80cc\u5f8c\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u5c24\u5176\u662f\u7aef\u7c92\u9176\u8abf\u63a7\u3001\u6c27\u5316\u640d\u50b7\u4fee\u5fa9\u53ca\u7d30\u80de\u51cb\u4ea1\u8def\u5f91\u3002\u6b64\u5916\uff0c\u96a8\u8457\u672a\u4f86\u6df1\u7a7a\u4efb\u52d9\u7684\u589e\u591a\uff0c\u5982\u4f55\u958b\u767c\u6709\u6548\u7684\u751f\u7269\u9632\u8b77\u548c\u6062\u5fa9\u5e72\u9810\u63aa\u65bd\uff0c\u4ee5\u6e1b\u5c11DNA\u640d\u50b7\u548c\u7aef\u7c92\u640d\u8017\uff0c\u5c07\u662f\u4fdd\u969c\u592a\u7a7a\u4eba\u9577\u671f\u5065\u5eb7\u7684\u95dc\u9375\u3002<\/li>\n<\/ol>\n\n\n\n
    \u7e3d\u7d50\uff1a<\/h5>\n\n\n\n

    Luxton\u7b49\u4eba\u7684\u7814\u7a76\u4ee5\u56b4\u8b39\u7684\u6642\u9593\u5e8f\u5217\u8ffd\u8e64\u65b9\u6cd5\uff0c\u63ed\u793a\u4e86\u592a\u7a7a\u8f3b\u5c04\u74b0\u5883\u4e0b\u7aef\u7c92\u9577\u5ea6\u548cDNA\u640d\u50b7\u53cd\u61c9\u7684\u52d5\u614b\u8b8a\u5316\uff0c\u5f37\u8abf\u592a\u7a7a\u98db\u884c\u5c0d\u7d30\u80de\u8001\u5316\u904e\u7a0b\u7684\u96d9\u91cd\u5f71\u97ff\u3002\u8a72\u7814\u7a76\u4e0d\u50c5\u6df1\u5316\u4e86\u6211\u5011\u5c0d\u592a\u7a7a\u751f\u7406\u5b78\u7684\u8a8d\u8b58\uff0c\u4e5f\u70ba\u672a\u4f86\u592a\u7a7a\u4efb\u52d9\u4e2d\u7d30\u80de\u5065\u5eb7\u7684\u76e3\u63a7\u8207\u5e72\u9810\u63d0\u4f9b\u4e86\u79d1\u5b78\u57fa\u790e\uff0c\u5177\u6709\u91cd\u8981\u7684\u7406\u8ad6\u50f9\u503c\u548c\u61c9\u7528\u524d\u666f\u3002<\/p>\n\n\n\n

    \n\n\n\n

    Source: <\/p>\n\n\n\n

    Temporal Telomere and DNA Damage Responses in the Space Radiation Environment<\/strong><\/a><\/p>\n\n\n\n

    Translator and Reviewer: PI-Union Medical Science Ltd.<\/a><\/strong><\/p>\n\n\n\n

    \u7de8\u8b6f\u8207\u8a55\u8ad6: \u767e\u806f\u91ab\u5b78\u7de8\u8b6f<\/a><\/strong><\/p>\n\n\n\n